Bioequivalence Evaluation of Two Esomeprazole 20 mg Capsule Formulations in Healthy Male Bangladeshi Volunteers
نویسندگان
چکیده
Esomeprazole, the S-isomer of omeprazole was developed with the aim of improving the pharmacokinetic and pharmacodynamic profiles of racemic omeprazole [1]. It suppresses the secretion of hydrochloric acid from gastric parietal cells via inhibition of the H+/K+ adenosine triphosphatase enzyme like other proton pump inhibitors [2]. Among all proton pump inhibitors available, esomeprazole is the first to demonstrate significantly greater healing rates than omeprazole in the treatment of patients with erosive oesophagitis [3,4].
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